. 2023 May 3;14(5):471–487. doi: 10.1007/s12687-023-00645-z

Table 2.

Prognostic performance of PRSs for breast cancer and coronary artery disease

Disease	SNP selection	# SNPs (PRS)	C statistic	Reference
Breast cancer	risk + GWS	77	0.622	Mavaddat et al. (2015)
88	0.541¹ 0.566²	Kuchenbaecker et al. (2017)
Coronary artery disease	penalized regression	40,079	0.608	Elliott et al. (2020)

Disease

SNP selection

# SNPs (PRS)

C statistic

Reference

Breast cancer

risk + GWS

0.622

Mavaddat et al. (2015)

0.541¹

0.566²

Kuchenbaecker et al. (2017)

Coronary artery disease

penalized regression

40,079

0.608

Elliott et al. (2020)

PRS: polygenic risk score, SNP: single nucleotide polymorphism, # SNP (PRS): number of SNPs included in the PRS, GWS: genome-wide significant, C statistic: Harrell’s C statistic, ¹BRCA1 mutation carriers, ²BRCA2 mutation carriers.