TABLE 2.

MICs of sanfetrinem and comparator drugs for β-lactamase inducibility mutants^a

Strain	MIC (μg/ml)
	Sanfetrinem	Imipenem	Amoxicillin	Cefixime	Cefpodoxime
C. freundii
C 2	1	0.25	512	2	4
C 2-con	4	0.25	>512	>128	>128
C 2-def	0.25	0.12	32	64	16
C 4	0.5	0.5	256	1	2
C 4-con	2	0.25	>512	>128	>128
C 4-def	0.5	0.25	128	4	8
C 10	0.5	0.5	64	1	1
C 10-con	2	0.25	>512	>128	>128
C 10-def	0.12	0.25	2	0.25	0.25
C 12	0.25	0.25	64	0.5	1
C 12-con	4	0.25	>512	128	>128
C 12-def	0.12	0.06	>512	0.5	0.25
E. cloacae
84-con	8	0.5	>512	>128	>128
84-def	0.5	0.25	256	64	64
100-con	0.5	0.12	512	>128	>128
100-def	0.25	0.25	4	1	2
684	2	0.25	>512	4	8
684-con	4	0.25	512	>128	>128
684-def	0.06	0.06	2	0.5	1
M. morganii
M 1	1	1	512	0.5	4
M 1-con	1	1	>512	32	64
M 1-def	0.5	1	4	0.06	0.25
M 6	0.5	1	512	0.12	0.5
M 6-con	0.5	1	>512	16	64
M 6-def	0.12	0.5	8	0.12	0.25
S. marcescens
S 2	1	0.5	128	0.25	1
S 2-con	2	0.5	256	8	16
S 2-def	1	0.5	128	0.25	1
S 7	1	0.5	128	0.5	0.5
S 7-con	2	1	256	32	64
S 7-def	2	0.5	128	0.25	1
P. vulgaris
Va1	0.12	0.5	>512	≤0.015	0.25
Va1-con	0.12	0.25	>512	0.06	8
Va1-def	0.06	0.12	2	≤0.015	0.06
V 2	0.12	0.25	>512	≤0.015	0.25
V 2-con	0.12	0.25	>512	≤0.015	2
V 2-def	0.12	0.25	16	≤0.015	0.12
V2	0.12	0.5	>512	0.015	0.25
V2-con	0.12	0.25	>512	0.06	8
V2-def	0.12	0.12	2	0.015	0.06
V3	0.06	0.25	>512	0.015	0.25
V3-con	0.06	0.25	>512	0.015	2
V3-def	0.06	0.25	16	0.015	0.12
S. maltophilia
10257 L1, L2 ind	>64	>64	>512	>128	>128
10257 L1, L2 con	>64	>64	>512	>128	>128
10257 L1, L2 def	2	2	8	8	8
10257 L1 def, L2 ind	2	2	8	8	8
10499 L1, L2 ind	>64	>64	>512	>128	>128
10499 L1, L2 con	>64	>64	>512	>128	>128
10499 L1, L2 def	4	8	16	16	8

^aOrganisms indicated by unsuffixed numbers and those with the suffix ind were inducible for the chromosomal β-lactamases, those indicated by numbers and the suffix con were derepressed for the enzymes, and those indicated by numbers and the suffix def were basal for these enzymes. Full details of the strains and their β-lactamase expression characteristics are given elsewhere (2, 33–35).