TABLE 3.
Selection of resistant mutants by sanfetrinem
| Isolate | MIC (μg/ml) | Two times the MIC
|
Four times the MIC
|
Eight times the MIC
|
Mutation frequency at 16 times the MIC | |||
|---|---|---|---|---|---|---|---|---|
| Mutation frequency | No. derepressed/no. tested | Mutation frequency | No. derepressed/no. tested | Mutation frequency | No. derepressed/no. tested | |||
| E. cloacae | ||||||||
| 238 | 0.5 | 1 × 10−7 | 10/10 | <1 × 10−9 | <1 × 10−9 | <1 × 10−9 | ||
| 467 | 0.5 | 7 × 10−7 | 8/10 | 1.6 × 10−7 | 10/10 | <1 × 10−9 | <1 × 10−9 | |
| 751 | 0.5 | 2.8 × 10−6 | 10/10 | 1.2 × 10−7 | 10/10 | <1 × 10−9 | <1 × 10−9 | |
| 206 | 2 | 9 × 10−7 | 10/10 | <1 × 10−9 | <1 × 10−9 | <1 × 10−9 | ||
| 684 | 2 | 1.4 × 10−7 | 10/10 | <1 × 10−9 | <1 × 10−9 | <1 × 10−9 | ||
| C. freundii | ||||||||
| C10 | 0.25 | 5 × 10−7 | 8/10 | 7.3 × 10−8 | 10/10 | 6.6 × 10−9 | 10/10 | <1 × 10−9 |
| C12 | 0.25 | 7.9 × 10−7 | 4/10 | 4.4 × 10−7 | 8/10 | 1.1 × 10−7 | 10/10 | <1 × 10−9 |
| 722 | 0.5 | 5.2 × 10−7 | 6/10 | 4.6 × 10−8 | 8/10 | <1 × 10−9 | <1 × 10−9 | |
| C2 | 1 | 2.1 × 10−7 | 10/10 | 4.7 × 10−8 | 10/10 | <1 × 10−9 | <1 × 10−9 | |
| C4 | 1 | 3.3 × 10−8 | 5/5 | <1 × 10−9 | <1 × 10−9 | <1 × 10−9 | ||
| M. morganii | ||||||||
| M6 | 0.5 | 3 × 10−7 | 10/10 | 5 × 10−8 | 9/10 | <1 × 10−9 | <1 × 10−9 | |
| M1 | 1 | 2.5 × 10−7 | 10/10 | 6 × 10−8 | 10/10 | <1 × 10−9 | <1 × 10−9 | |
| 8 | 1 | 2.2 × 10−7 | 10/10 | 8 × 10−9 | 2/2 | <1 × 10−9 | <1 × 10−9 | |
| 11 | 1 | 6.5 × 10−7 | 10/10 | 3.2 × 10−8 | 10/10 | <1 × 10−9 | <1 × 10−9 | |
| 276 | 1 | 1.3 × 10−7 | 10/10 | 3.3 × 10−8 | 10/10 | <1 × 10−9 | <1 × 10−9 | |
| S. marcescens | ||||||||
| 999 | 1 | 3.3 × 10−7 | 0/10 | 1.1 × 10−7 | 0/10 | <1 × 10−9 | <1 × 10−9 | |
| 951 | 2 | 4.6 × 10−7 | 6/10 | <1 × 10−9 | <1 × 10−9 | <1 × 10−9 | ||
| S2 | 2 | 3.3 × 10−8 | 7/7 | <1 × 10−9 | <1 × 10−9 | <1 × 10−9 | ||
| S7 | 2 | 1.3 × 10−7 | 10/10 | <1 × 10−9 | <1 × 10−9 | <1 × 10−9 | ||
| 834 | 4 | 9.4 × 10−9 | 3/3 | <1 × 10−9 | <1 × 10−9 | <1 × 10−9 | ||