Table 3.

The correlations between plasma biomarkers and subscores of ACE-R or MoCA-J in the PD group

	GFAP		NfL		p-tau181		Aβ42/40		Aβ40		Aβ42
	rs	p value	rs	p value	rs	p value	rs	p value	rs	p value	rs	p value
ACE-R
Attention/orientation	− 0.5515	< 0.0001	− 0.3824	0.0012	− 0.2535	0.0342	0.2165	0.0718	− 0.2000	0.0969	− 0.1139	0.3476
Memory	− 0.3971	0.0007	− 0.3048	0.0109	− 0.1674	0.1659	0.1348	0.2658	− 0.2043	0.0898	− 0.1265	0.2968
Fluency	− 0.3494	0.0030	− 0.4815	< 0.0001	− 0.2674	0.0253	0.1717	0.1552	− 0.3159	0.0077	− 0.1550	0.2000
Language	− 0.2983	0.0121	− 0.2765	0.0214	− 0.0211	0.8621	0.0405	0.7391	− 0.1426	0.2389	− 0.1528	0.2068
Visuospatial	− 0.5041	< 0.0001	− 0.6111	< 0.0001	− 0.4097	0.0004	0.2353	0.0499	− 0.4047	0.0005	− 0.1915	0.1122
MoCA-J
Attention	− 0.4118	0.0004	− 0.2474	0.0404	− 0.0948	0.4350	0.2439	0.0419	− 0.1555	0.1987	− 0.0193	0.8741
Orientation	− 0.4591	< 0.0001	− 0.4003	0.0007	− 0.3021	0.0116	0.3644	0.0021	− 0.2240	0.0642	0.0115	0.9255
Executive function	− 0.2577	0.0313	− 0.3423	0.0040	− 0.0404	0.7397	0.2182	0.0695	− 0.1176	0.3323	0.0106	0.9304
Memory	− 0.4221	0.0003	− 0.2561	0.0350	− 0.2078	0.0866	0.0305	0.8034	− 0.0407	0.7401	− 0.0526	0.6680
Language	− 0.2390	0.0463	− 0.2269	0.0608	− 0.0705	0.5618	0.1069	0.3786	− 0.1037	0.3931	− 0.0149	0.9025
Visuospatial function	− 0.3142	0.0081	− 0.3723	0.0016	− 0.1492	0.2176	0.0835	0.4918	− 0.1189	0.3267	− 0.0212	0.8616

Spearman’s rank correlation test was used to determine significant correlations

GFAP glial fibrillary acidic protein, NfL neurofilament light chain, p-tau phosphorylated tau, Aβ amyloid beta, PD Parkinson's disease, ACE-R Addenbrooke’s Cognitive Examination-Revised, MoCA-J Japanese version of the Montreal Cognitive Assessment

*Bold letters indicate a correlation with a statistically significant difference

**Underlines indicate a moderate or higher correlation coefficient (absolute value of rs > 0.4)