Table 5.
The results of the generalized linear models for ACE-R and MoCA-J based on plasma biomarkers and possible confounders in the PD group
| Covariate/factor | Estimate | LR chi-square | p value | Lower 95% | Upper 95% |
|---|---|---|---|---|---|
| ACE-R | |||||
| GFAP | − 0.0008 | 6.7921 | 0.0092 | − 0.0013 | − 0.0002 |
| NfL | − 0.0016 | 8.6069 | 0.0033 | − 0.0027 | − 0.0005 |
| p-tau181 | 0.0128 | 0.7994 | 0.3713 | − 0.0153 | 0.0406 |
| Aβ40 | − 0.0001 | 0.0048 | 0.9449 | − 0.0017 | 0.0015 |
| Age at examination | − 0.0026 | 1.6561 | 0.1981 | − 0.0066 | 0.0014 |
| Education | 0.0233 | 13.6439 | 0.0002 | 0.0109 | 0.0356 |
| HY | − 0.0254 | 3.0001 | 0.0833 | − 0.0542 | 0.0033 |
| MoCA-J- | |||||
| GFAP | − 0.0010 | 3.4262 | 0.0642 | − 0.0021 | 0.0001 |
| NfL | − 0.0021 | 3.7233 | 0.0537 | − 0.0042 | < 0.0001 |
| Age at examination | − 0.0046 | 1.4057 | 0.2358 | − 0.0123 | 0.0030 |
| Education | 0.0115 | 1.0167 | 0.3133 | − 0.0108 | 0.0336 |
| HY | − 0.0406 | 2.0441 | 0.1528 | − 0.0963 | 0.0151 |
ACE-R Addenbrooke’s Cognitive Examination-Revised, MoCA-J Japanese version of the Montreal Cognitive Assessment, PD Parkinson's disease, GFAP glial fibrillary acidic protein, NfL neurofilament light chain, p-tau phosphorylated tau, Aβ amyloid beta, HY Hoehn − Yahr scale, LR likelihood ratio
*Bold letters indicate a correlation with a statistically significant difference