Fig. 1.

Clinical course of each patient receiving standard-frequency anti-PD-1 therapy followed by reduced-frequency dosing. This swimmer’s plot portrays duration of treatment, best overall response, clinically significant immune-related adverse events, and disease progression or death in 23 patients who received standard frequency dosing of anti-PD-1 (SFD) then transitioned to reduced-frequency dosing (RFD). Each patient received SFD (dark gray) until objective response or disease control was achieved, followed by transition to RFD (light gray) guided by timing of disease response. The median duration of therapy at SFD was 13.1 months (range 2.3–26.0), and the median duration of RFD was 14.5 months (range 2.1–42.1). Abbreviations SFD—Standard frequency dosing, RFD—Reduced frequency dosing, CR—Complete response, PR—Partial response, SD—Stable disease, PD—Progressive disease