Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 21;72(11):3839–3850. doi: 10.1007/s00262-023-03539-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Case study suggesting dependence on continuous PD-1 blockade for disease control (patient Melanoma-15 from Fig. 1) Adult male with metastatic melanoma was treated with pembrolizumab for 47 months (26 months at standard-frequency dosing (SFD) and 21 months at reduced-frequency dosing (RFD) before he electively discontinued ICI (panel A). 14 months after elective discontinuation, his disease progressed (panel B), suggesting potential role of prolonged PD-1 blockade in controlling his disease. Reintroduction of nivolumab at SFD has recaptured his disease response (panel C), which is ongoing at 35 months after restarting nivolumab. This case suggests the importance of continuous PD-1 blockade in maintaining immune equilibrium in patients with residual disease