Table 5.
Candidate drugs targeting genes with AD.
| Drug | Gene | Interaction score | Clinical application |
|---|---|---|---|
| SUCRALFATE | FGF2 | 5.89 | Approved |
| REBAMIPIDE | FGF2 | 1.96 | Approved, investigational |
| FAMOTIDINE | FGF2 | 1.47 | Approved |
| ABT-510 | FGF2 | 1.47 | Investigational |
| PYRAZOLE | FGF2 | 1.47 | Experimental |
| THYROTROPIN | FGF2 | 1.18 | Investigational |
| SQUALAMINE | FGF2 | 0.74 | Investigational |
| QUIZARTINIB | FGF2 | 0.65 | Approved, investigational |
| FP-1039 | FGF2 | 0.59 | Unsearchable |
| PHENYLEPHRINE | FGF2 | 0.42 | Approved |
| HYDROGEN PEROXIDE | PTPRC | 10.3 | Approved, vet approved |
| CHEMBL204543 | PTPRC | 5.15 | Unsearchable |
| APAMISTAMAB IODINE I-131 | PTPRC | 5.15 | Investigational |
| ALENDRONIC ACID | PTPRC | 1.29 | Approved |
| ADALIMUMAB | PTPRC | 0.91 | Approved, experimental |
| ETANERCEPT | PTPRC | 0.81 | Approved, investigational |
| INFLIXIMAB | PTPRC | 0.77 | Approved |
| EPOETIN BETA | PTPRC | 0.74 | Approved |
| ESTRADIOL | PTPRC | 0.34 | Approved, investigational, vet approved |
| PREDNISONE | PTPRC | 0.32 | Approved, vet approved |
| HYALURONAN | CD44 | 6.87 | Approved, vet approved |
| GENTAMICIN | CD44 | 1.96 | Approved, vet approved |
| PROGESTERONE | CD44 | 0.62 | Approved, vet approved |
| ASK-8007 | SPP1 | 10.3 | unsearchable |
| CALCITONIN | SPP1 | 3.43 | Approved, investigational |
| GENTAMICIN | SPP1 | 0.98 | Approved, vet approved |
| ALTEPLASE | SPP1 | 1.08 | Approved, investigational |
| TACROLIMUS | SPP1 | 0.61 | Approved, investigational |
| WORTMANNIN | SPP1 | 0.74 | Experimental |
The bold text represents drugs that have been studied in relation to Alzheimer's disease.