TABLE 3.

Effects of LPS on the pharmacokinetic parameters of CPZ in rats pretreated or not pretreated with G-CSF^a

Treatment	VSS (liter/kg)	CLSYS (liters/h/kg)	MRT (h)
Control	0.342 ± 0.024	1.621 ± 0.145	0.194 ± 0.014
G-CSF	0.326 ± 0.022	1.398 ± 0.057	0.213 ± 0.012
LPS	0.416 ± 0.032	0.908 ± 0.111b,c	0.492 ± 0.093d,e
G-CSF and LPS	0.306 ± 0.022f	0.423 ± 0.076b,c,g	0.822 ± 0.179b,c

^aEach value represents the mean ± standard error (n = 5 or 6). 

^bSignificantly different from the control group (P < 0.01). 

^cSignificantly different from the G-CSF-treated group (P < 0.01). 

^dSignificantly different from the control group (P < 0.05). 

^eSignificantly different from the G-CSF-treated group (P < 0.05). 

^fSignificantly different from the LPS-treated group (P < 0.05). 

^gSignificantly different from the LPS-treated group (P < 0.05).