TABLE 4.

Effects of LPS on biliary and urinary excretion of CPZ in rats pretreated or not pretreated with G-CSF^a

Treatment	Bile		Urine
	% of dose excreted	CLBILE (liters/h/kg)	% of dose excreted	CLR (liters/h/kg)
Control	70.06 ± 3.62	1.286 ± 0.106	20.10 ± 1.25	0.334 ± 0.047
G-CSF	72.97 ± 1.62	1.028 ± 0.038	21.55 ± 2.04	0.306 ± 0.033
LPS	60.02 ± 3.71b,c	0.582 ± 0.091b,d	23.73 ± 4.59	0.217 ± 0.036
G-CSF and LPS	43.84 ± 7.07b,d	0.214 ± 0.049b,d,e	36.27 ± 2.76b,d	0.172 ± 0.033c,f

^aEach value represents the mean ± standard error (n = 5 or 6). 

^bSignificantly different from the control group (P < 0.01). 

^cSignificantly different from the G-CSF-treated group (P < 0.05). 

^dSignificantly different from the G-CSF-treated group (P < 0.01). 

^eSignificantly different from the LPS-treated group (P < 0.05). 

^fSignificantly different from the control group (P < 0.05).