Table 4.
Genotype and allelic frequency distribution of OPG (TNFRSF11B) rs2073618 gene polymorphism between T2D patients with HTN (n = 177) and healthy control (n = 191).
| Genotypes& alleles | T2D with HTN (n = 177) | Healthy control (n = 191) | OR (95% CI) | P value |
|---|---|---|---|---|
| Genotypes | ||||
| CC (2) | 52 (29.4%) | 71 (37.2%) | Ref | –– |
| GC (1) | 81 (45.8%) | 98 (51.3%) | 1.12 (0.70–1.77) | 0.60 |
| GG (0) | 44 (24.9%) | 22 (11.5%) | 2.79 (1.44–5.21) | 0.0014 |
| Alleles | ||||
| C | 185 (52%) | 240 (62%) | Ref | 0.003 |
| G | 169 (48%) | 142 (38%) | 1.54 (1.15–2.07) | |
| Genetic models | ||||
| Dominant | ||||
| CC | 52 (29.4%) | 71 (37.2%) | Ref | 0.11 |
| GC + GG | 125 (70.6%) | 120 (62.8%) | 1.42 (0.92–2.20) | |
| Recessive | ||||
| CC + GC | 135 (79.9%) | 168 (88%) | Ref | 0.0008 |
| GG | 34 (20.1%) | 23 (12%) | 2.54 (1.45–4.45) | |
| Homozygotic | ||||
| CC | 52 (29.4%) | 71 (37.2%) | Ref | 0.0014 |
| GG | 44 (24.9%) | 23 (11%) | 2.79 (1.44–5.21) | |
Genetic model reference; OR: Odds ratio; Ref: Reference; CI: Confidence interval.