Table 5.
Genotype and allelic frequency distribution of OPG (TNFRSF11B) rs2073618 gene polymorphism between T2D patients with HTN and without HTN.
| Genotypes & alleles | T2D with HTN (n = 177) | T2D without HTN(n = 172) | OR (95% CI) | P value |
|---|---|---|---|---|
| Genotypes | ||||
| CC (2) | 52 (29.4%) | 71(41.3%) | Ref | – |
| GC (1) | 81 (45.8%) | 81 (47.1%) | 1.36 (0.86–2.18) | 0.13 |
| GG (0) | 44 (24.9%) | 20 (11.6%) | 3.004 (1.55–5.58) | 0.0006 |
| Alleles | ||||
| C | 185 (52%) | 223 (64%) | Ref | 0.0008 |
| G | 169 (48%) | 121 (36%) | 1.68 (1.24–2.28) | |
| Genetic models | ||||
| Dominant | ||||
| CC | 52 (29.4%) | 71 (41.3%) | Ref | 0.02 |
| GC + GG | 125 (70.6%) | 101 (58.7%) | 1.69 (1.08–2.63) | |
| Recessive | ||||
| CC + GC | 133 (75.1%) | 152 (88.4%) | Ref | |
| GG | 44 (24.9%) | 20 (11.6%) | 2.51 (1.14–4.48) | 0.0001 |
| Homozygotic | ||||
| CC | 52 (29.4%) | 71 (41.3%) | Ref | |
| GG | 44 (24.9%) | 20 (11.6%) | 3.004 (1.55–5.58) | 0.0006 |
Genetic model reference; OR: Odds ratio; Ref: Reference; CI: Confidence interval.