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. Author manuscript; available in PMC: 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Apr 15;42(4):112402. doi: 10.1016/j.celrep.2023.112402

Figure 4. Neutralizing antibody levels and neutrophil phagocytic activity are elevated in surviving, vaccinated NHPs.

Figure 4.

Induction of GP- and sGP-specific antibody-mediated innate immune effector and MIP-1B and sGP-specific antibodies to human Fc receptors (FcγR2a H131, FcγR3A F158, FcγR3B) and rhesus Fc receptors (FcγR2A-3, FcγR3A-1, FcγR3A-3) were measured. Data across all animals and time points were Z scored, and the Z score of each animal at the final time point before challenge was analyzed in an unsupervised hierarchical clustered heatmap (purple is row maximum [max]; green is row minimum [min]). Surviving animals are indicated by a red bar beneath challenge time point, and non-surviving animals are indicated by a blue bar. Statistically significant differences between surviving and non-surviving animals at this final time point are indicated to the right of the heatmap across all challenge time points (left column) or only at the durability time points of 3 months and 1 year post-vaccination (right column). *p < 0.05, **p < 0.005, and ***p < 0.001 by Mann-Whitney analysis with Benjamini-Hochberg correction for false discovery rate.