Table 2.

The effects of EGCG on microRNAs in various cancers

microRNA	Study type	Model	Target	Effects	Refs.
miR-21, miR-16	In vitro	Breast cancer	Down	Controlling NF-kB	[104]
hsa-miR-204, hsa-miR-222, hsa-miR-21, hsa-miR-146b, hsa-miR-221	In vitro	Thyroid cancer	Up	Improving the apoptosis	[100]
miR-106b, miR-93, miR-92	In vitro	Malignant neuroblastoma	Down	Improving the apoptosis	[105]
miR-99a, miR-34a, miR-7-1	In vitro	Malignant neuroblastoma	Up	Improving the apoptosis	[105]
miR-27, miR-21	In vitro	Breast cancer	Dow	Changes in the miRNA control of possible cancer-causing genes and tumor-suppressing genes	[10]
miR-16	In vivo	Breast cancer	Up	NF-κB pathway	[106]
miR-485	In vivo	Non-small cell lung cancer	Up	Control miR-485/CD44 axis	[107]
hsa-mir-485-5p	In vivo	Non-small cell lung cancer	Up	Control the hsa-mir-485-5p/RXRα axis	[108]
miR483-3p	In vivo	Hepatocellular carcinoma cells	Down	Hypermethylation of the miR483-3p promoter region	[109]
miR-155-5p	In vitro	Colorectal Cancer	Up	Suppressing GRP78/NF-κB/miR-155-5p/MDR1 Pathway	[110]
miR-1226-3p, miR-185-3p, miR-642a-5p, miR-3116, miR-31-5p,	In vitro	Bladder cancer	Up	Modulation Hippo signaling pathway	[111]
hsa-miR-1915 hsa-miR-29b-1-5p hsa-miR-210 hsa-miR-1225-5p hsa-miR-1202 hsa-miR-1246 hsa-miR-1973 hsa-miR-3162 hsa-miR-4281 hsa-miR-3656 hsa-miR-3665 hsa-miR-1207-5p hsa-miR-3196 hsa-miR-34a hsa-miR-2861	In vitro	Nasopharyngeal carcinoma	Up	Apoptosis, Cell cycle, Cell proliferation	[112]
miR-296	In vitro	Nasopharyngeal Carcinoma	Up	Suppressing migratory properties of anoikis-resistant cells	[113]
miR-34a, let-7a	In vitro	Hepatocellular carcinoma	Up	Improving cytotoxicity and inducing the apoptotic pathway	[114]
miR-195	In vitro	Prostate cancer	Up	Affect on EMT	[115]
miR-181a	In vitro	Prostate Cancer	Up	Prompting the cellular apoptosis	[116]
miRNA-21	In vivo	Prostate cancer	Down	Suppressing cells growth and Antagonist of AR signaling and	[117]
miRNA-330	In vivo	Prostate cancer	Up	Suppressing cells growth and antagonist of AR signaling and	[117]
miR-200c, miR-145, miR-34a,	In vitro	Colorectal cancer	Up	Suppressing Notch and Bmi1, Ezh2, and Suz12	[118]
miR-210	In vitro	Lung cancer	Up	Anti-proliferation	[8]
miR-30e-3p	In vitro	Malignant melanoma	Up	Controlling circ_MITF/miR-30e-3p/HDAC2 axis	[119]
microRNA-let-7b	In vitro	Malignant melanoma	Up	Down-modulstion of high mobility group A2 (HMGA2)	[120]
miR-204	In vitro	Oral squamous cell carcinomas	Down	miR204-mediated inhibition of Sox4 and Slug	[121]
miR-25	In vitro	Breast cancer	Down	Anti-proliferation and pro-apoptosis	[9]
let-7	In vitro	Lung cancer	Up	Let-7 signaling pathway	[122]
hsa-miR-98-5p	In vitro	Non-small cell lung cancer	Down	Elevating of p53	[123]
miR-133a/b	In vivo	Prostatic hyperplasia	Down		[124]
miR-203, miR-125b	In vitro	Cervical carcinoma	Down	Induce cell cycle arrest and apoptosis	[99]
miR-29a, miR-210, miR-29, miR-203, miR-125b,	In vitro	Cervical carcinoma	Up	Induce cell cycle arrest and apoptosis	[99]