TABLE 1.

Summary of pharmacokinetic parameters after dosing for 10 days^a

Agent	Cmax		Ratio of LSM (95% CI)	Tmax (h)		AUC		Ratio of LSM (95% CI)
	Single agent	Combination		Single agent	Combination	Single agent	Combination
Clarithromycin	3.27 ± 1.24	3.26 ± 1.17	1.04 (0.78–1.38)	2.9 ± 2.6	2.6 ± 2.2	26.0 ± 9.7	27.4 ± 9.7	1.07 (0.84–1.35)
14(R)-Hydroxy-clarithromycin	0.74 ± 0.22	0.76 ± 0.19	0.99 (0.81–1.20)	2.8 ± 2.1	2.3 ± 0.8	6.81 ± 2.05	7.15 ± 1.75	1.00 (0.84–1.20)
Loratadine	4.12 ± 4.45	7.25 ± 12.5b	1.36 (1.17–1.60)	1.3 ± 0.5	1.5 ± 0.6	14.6 ± 23.7	40.8 ± 116b	1.76 (1.48–2.09)
DCL	3.89 ± 2.41	6.41 ± 3.30b	1.69 (1.53–1.86)	2.9 ± 2.3	2.0 ± 0.8b	52.7 ± 49.1	79.2 ± 77.1b	1.49 (1.38–1.60)

^an = 23. Values, except for ratios and 95% confidence intervals (CI), are shown as means ± standard deviations. LSM, least-squares means obtained from ANOVA. C_max values are expressed as micrograms per milliliter for clarithromycin and 14(R)-hydroxy-clarithromycin and as nanograms per milliliter for loratadine and DCL. AUC values are for 0 to 12 h, in micrograms · hour per milliliter, for clarithromycin and 14(R)-hydroxy-clarithromycin and for 0 to 24 h, in nanograms · hour per milliliter, for loratadine and DCL. 

^bP ≤ 0.05 (ANOVA).