TABLE 2.
MICs of various drugs for strains producing Toho-2 β-lactamase
| Drug | MIC (μg/ml) for E. coli strain:
|
||
|---|---|---|---|
| TUM1083 | ML4909(pMTY002) | ML4909 | |
| Ampicillin | >512 | >512 | 1.0 |
| Carbenicillin | >512 | >512 | 2.0 |
| Piperacillin | >512 | 512 | 0.5 |
| Cephalothin | >512 | 512 | 4.0 |
| Cefoxitin | 64 | 0.5 | 1.0 |
| Ceftizoxime | 128 | 1.0 | ≤0.3 |
| Cefotaxime | >512 | 256 | ≤0.3 |
| Ceftazidime | 4.0 | 0.5 | ≤0.3 |
| Cefuzonam | >512 | 512 | ≤0.3 |
| Moxalactam | 1.0 | ≤0.3 | ≤0.3 |
| Aztreonam | 256 | 4.0 | ≤0.3 |
| Imipenem | ≤0.3 | 0.5 | 0.5 |
| Piperacillin-tazobactama | 16 | 2.0 | 0.5 |
a
Tested at a ratio of 4:1, respectively.