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Kinetic parameters of Toho-2 β-lactamase
| Antibiotic | kcata (s−1) | Km or apparent Ki (μM) | kcat/Km (μM−1s−1) |
|---|---|---|---|
| Penicillin G | 3.6 | 6 | 0.6 |
| Ampicillin | 1.2 | 12 | 0.1 |
| Oxacillin | 9.1 | 91 | 0.1 |
| Carbenicillin | 14 | 18 | 0.8 |
| Piperacillin | 130 | 84 | 1.6 |
| Cephalothin | 12,000 | 470 | 25 |
| Cephaloridine | 4,500 | 180 | 25 |
| Cefoxitin | <0.1 | 4.8 | <0.1 |
| Ceftizoxime | 30 | 150 | 0.2 |
| Ceftazidime | 1.3 | 160 | <0.1 |
| Cefotaxime | 220 | 66 | 3.3 |
| Aztreonam | 0.1 | 140 | <0.1 |
| Imipenem | 4.8 | ||
| Clavulanic acid | 2.4 | ||
| Sulbactam | 4.5 | ||
| Tazobactam | 0.3 |
Absolute kcat value.
