Table 1.

Summary of unconditional analysis, conditional analyses, and replication

Method	LDL-C	TC	HDL-C	TG	Total number
STAAR unconditional analysisa	28	20	19	16	83
Conditioning on known lipid GWAS variantsb	20	14	15	12	61
Conditioning on rare nonsynonymous variants within the closest gene and nearby lipid monogenic genesc	18	13	15	12	58
Conditioning on rare synonymous variants within the closest gene and nearby lipid monogenic genesc	20	14	15	12	61
Conditioning on rare pLoF variants within the closest gene and nearby lipid monogenic genesc	20	14	15	12	61
Replication in UKB WGSc	13	7	8	6	34

Numbers are count of significant lipid-associated lncRNAs. Results are available in Table S5. STAAR, variant-set test for association using annotation information; GWAS, genome-wide association study; UKB, UK Biobank; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglycerides; lncRNA, long non-coding RNA.

^aBonferroni correction level of 0.05/111,550 = 4.5 × 10⁻⁰⁷.

^bBonferroni correction level of 0.05/83 = 6.0 × 10⁻⁰⁴.

^cBonferroni correction level of 0.05/61 = 8.2 × 10⁻⁰⁴.