Figure 3.

Colocalization between GWAS signals for SBP and multi-tissue expression data at locus ID 580 on chromosome 17

The top panel shows the unconditional GWAS data of the genomic region at chromosome 17 (60.2–62.9Mb) for SBP. The lower four panels show the log-annotation-informed Bayesian factors of the conditional GWAS signal (blue, left axis) and gene expression data from GTEx eQTL data (red, right axis). Three distinct annotation-informed signals colocalized with gene expression data from MRC2 (second panel) in tibial artery tissue, ACE (third panel) in kidney cortex tissue, and CEP95 and DDX5 in aortic artery tissue (bottom panels). The x axis shows the physical position on the chromosome (Mb) and the y axes show the log annotation-informed Bayesian factor from the GWAS (left axis) and the gene expression data (right axis). The intensity of the color indicates the linkage disequilibrium with respect to the sentinel GWAS SNP (blue) or top eQTL SNP (red).