TABLE 1.
Natural products of Phenols modulate NLRP3 protection in UC.
| Natural products | Phenols | ||
|---|---|---|---|
| Ingredient/Dose | Pineapple Leaf Phenols 200 mg/kg; 20 μg/mL | Rosmarinic acid 5,10,20 mg/kg | Resveratrol 50,100,200 mg/kg |
| Chemical name | (2R)-3-(3,4-Dihydroxyphenyl)-2-(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy propanoic acid | 3,5,4′-trihydroxy-trans-stilbene | |
| Chemical formula | C18H16O8 | C14H12O3 | |
| Type of cells | LPS-induced RAW 264.7 cells; DSS-induced Caco-2 cells | ||
| Model of UC | DSS-induced UC mice | DSS-induced UC mice | Radiation-induced IBD mice |
| Route of administration | Oral | Oral | Oral |
| Mechanism | Inhibit NF-κB activation and expression of pro-IL-1β; ZO-1, occludin, and claudin 1↑ | Upregulate NRF2/HO-1 expression; Reduction of NLRP3, ASC, cleaved caspase-1 expression | NLRP3, IL-1β, TNF-α↓ |
| References | Chen et al. (2021) | Marinho et al. (2021) | Sun et al. (2020) |