. 1998 Sep;42(9):2193–2196. doi: 10.1128/aac.42.9.2193

TABLE 2.

Mutations identified in the GyrA and ParC containing QRDRs in sparfloxacin-resistant clinical isolates of S. pneumoniae

Strain	MIC (μg/ml)		Amino acid (nucleotide) at the indicated position:
	CPFX^a	SPFX^b	GyrA^c					ParC^d
	CPFX^a	SPFX^b	75	81	83	85	93	79	137
245	0.5	0.25	Tyr (TAT)	Ser (TCC)	Ile (ATT)	Glu (GAA)	Trp (TGG)	Ser (TCT)	Lys (AAG)
182	64	16	—^e	Phe (TTC)	—	—	—	Phe (TTT)	—
674	64	64	—	Phe (TTC)	—	—	—	Phe (TTT)	—
354	64	128	Tyr (TAC)	—	—	Lys (AAA)	—	Tyr (TAT)	Asn (AAT)
252	64	128	Tyr (TAC)	—	Ile (ATC)	Lys (AAA)	Arg (CGG)	Tyr (TAT)	Asn (AAT)

CPFX, ciprofloxacin.

SPFX, sparfloxacin.

Amino acid position corresponding to that of S. pneumoniae GyrA (12).

Amino acid position corresponding to that of S. pneumoniae ParC (13).

—, no difference from fluoroquinolone-susceptible wild strain 245.