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. 2023 Oct 2;13:1237472. doi: 10.3389/fonc.2023.1237472

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Copyright © 2023 Burgard, Zacherl, Todica, Hornung, Grawe, Pekrul, Zimmermann, Schmid-Tannwald, Ladurner, Krenz, Trupka, Wagner, Bartenstein, Spitzweg and Wenter

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Planar whole-body scintigraphy and CT scan after the first radioiodine therapy (RIT) and during follow-up. A 14-year-old male patient (A) presenting with high residual thyroid bed uptake (orange arrow), an iodine-positive cervical lymph node metastasis in level II on the right side (green arrow), and multiple iodine-positive pulmonary metastases (red arrow) (B). Post-therapeutic scan of the second RIT showed ablation of the remnant thyroid tissue and significant uptake of pulmonary metastases (C). During follow-up, TSH was suppressed consequently; 1.6 years after the last RIT, Tg decreased to <0.1 ng/mL and pulmonary metastases could not be detected anymore in the subsequent CT scans (D). At the last visit, 8 years after the first RIT, the patient still presented with excellent response with Tg <0.1 ng/mL and no remarkable findings in computer tomography of the lung. st., stimulated; Tg, thyroglobulin; RIT, radioiodine therapy; TSH, thyroid-stimulating hormone.