Table 4.

Intercellular Space Values of Healthy Control, Gastroesophageal Reflux Disease Phenotypes and Functional Heartburn

Groups	HC	Mild ERD	Severe ERD	NERD	RH	FH
n	15	58	17	25	15	19
Mean (µm)	0.98	1.22a	1.35b	0.98	0.96	1.02
SD (µm)	0.23	0.25	0.24	0.31	0.27	0.29
Median (µm)	1.01	1.22	1.29	0.95	0.99	0.97
Minimum (µm)	0.54	0.54	0.89	0.52	0.46	0.62
Maximum (µm)	1.38	1.69	1.68	1.54	1.37	1.47

Bonferroni multiple comparison: ^amild erosive reflux disease (ERD) vs healthy control (HC) (P = 0.036), nonerosive reflux disease (NERD) (P = 0.004), reflux hypersensitivity (RH) (P = 0.014), ^bsevere ERD vs HC (P = 0.002), NERD (P < 0.001), RH (P = 0.001), functional heartburn (FH) (P = 0.004).