Table 2.
Outcomes in theoretical cohort of 400 000 pregnant individuals with advanced maternal age desiring cell-free DNA (cfDNA) aneuploidy screening, based on screening strategy involving first-trimester ultrasound (US) before cfDNA and strategy encompassing cfDNA only
| Screening strategy | Procedure-related loss | Pregnancy termination | LB with aneuploidy | LB with structural anomaly | Stillbirth |
|---|---|---|---|---|---|
|
| |||||
| cfDNA only | 473 | 1696 | 922 | 6501 | 2275 |
| US before cfDNA | 435 | 1789 | 835 | 6466 | 2271 |
| Difference between cfDNA only and US before cfDNA | 38 | −93 | 87 | 35 | 4 |
Data are given as n. LB, live birth.