Comparison 1. Antibiotic lock versus no antibiotic lock.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Confirmed catheter‐related infections	3	271	Risk Ratio (M‐H, Fixed, 95% CI)	0.15 [0.06, 0.40]
2 Suspected catheter‐related infections	3	271	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.22, 1.92]
3 Combined rate of suspected or confirmed catheter‐related infections (absolute rate)	3	271	Risk Ratio (M‐H, Fixed, 95% CI)	0.25 [0.12, 0.49]
4 Combined rate of suspected or confirmed catheter‐related infections (per 1000 catheter‐days)	2		Rate Ratio (Fixed, 95% CI)	0.17 [0.07, 0.40]
5 Mortality	2	186	Risk Ratio (M‐H, Fixed, 95% CI)	0.37 [0.13, 1.04]
6 Hypoglycaemic episodes	2	168	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.28, 0.92]
7 Adverse events (any)	2	168	Odds Ratio (M‐H, Fixed, 95% CI)	4.25 [0.47, 38.77]