Table 3.
Pairwise comparisons in the UKB test set and WHII validation sample to survive FDR corrections
| Risk score 1 | AUC for risk score 1 | Risk score 2 | AUC for risk score 2 | P | Pcorr |
| UKB | |||||
| UKBDRS | 0.80 | Age only | 0.77 | 9.54×10-6 | 9.54×10-6 |
| UKBDRS | 0.80 | ANU-ADRI | 0.57 | 2.62×10-62 | 1.05×10-61 |
| UKBDRS | 0.80 | CAIDE | 0.60 | 2.23×10-42 | 4.45×10-42 |
| UKBDRS | 0.80 | DRS | 0.77 | 5.64×10-7 | 7.53×10-7 |
| WHII | |||||
| UKBDRS | 0.77 | Age only | 0.74 | 3.20×10-3 | 5.97×10-3 |
| UKBDRS | 0.77 | ANU-ADRI | 0.52 | 8.16×10-11 | 3.27×10-10 |
| UKBDRS | 0.77 | CAIDE | 0.69 | 4.48×10-3 | 5.97×10-3 |
| UKBDRS | 0.77 | DRS | 0.74 | 1.07×10-2 | 1.07×10-2 |
The AUC of the UKBDRS was compared with each external risk score and an age-only model. If a comparison is not shown, there was no statistical difference in performance.
ANU-ADRI, Australian National University Alzheimer’s Disease Risk Index; AUC, area under the curve; CAIDE, Cardiovascular Risk Factors, Aging and Dementia; DRS, Dementia Risk Score; FDR, false discovery rate; UKB, UK Biobank; UKBDRS, UK Biobank Dementia Risk Score; WHII, Whitehall II.