TABLE 1.

Activity against gram-positive bacteria and C. albicans^a

Organism	MIC (μg/ml) of the following compounds in the presence of NaCl at the indicated concn:
	LL-37		HNP-1		PG-1		Vancomycin
	0 mM	100 mM	0 mM	100 mM	0 mM	100 mM	0 mM	100 mM
L. monocytogenes EGD	1.5	2.2	39.7	>79.1	0.8	0.7	TUb	TU
S. epidermidis	7.6	43.9	5.2	>250	0.7	1.1	6.0	8.8
S. aureus 930918-3	12.5	9.2	2.5	25.0	0.7	0.7	0.3	0.4
S. aureus 67395	2.9	5.4	7.9	>250	0.6	0.9	0.2	0.7
S. aureus 68721	3.2	9.0	6.8	>250	0.3	0.6	0.3	0.5
S. aureus 502A	3.6	7.2	2.2	>250	0.7	0.6	0.3	0.5
MRSA 1083	6.5	>79.1	2.5	>250	0.3	0.7	0.3	0.6
MRSA 30371	10.5	>79.1	25.0	>250	0.5	0.7	0.4	0.8
MRSA 54424-1	3.0	25.0	9.6	>250	0.4	0.6	0.3	0.3
MRSA ATCC 33591	3.4	>79.1	21.2	>250	0.5	0.7	0.9	1.2
B. subtilis	2.7	0.5	6.4	1.8	0.6	0.3	0.1	0.1
VREFc 94.132 (E. faecium)	0.7	0.6	2.7	1.0	0.2	0.5	>79.1	>79.1
VREFd CDC 21 (E. faecalis)	3.5	2.0	11.9	>250	1.6	0.7	20.7	7.2
C. albicans 820	>250	>250	>250	>250	0.4	2.9	>250	>250

^aRadial diffusion assays were performed with the standard low-salt underlays and with otherwise identical underlays that also contained 100 mM NaCl. MICs correspond to the x intercepts of plots such as those illustrated in Fig. 2. The molecular mass of vancomycin is 1,448. The masses of the peptides are as follows: LL-37, 4,493; HNP-1, 3,442; PG-1, 2,056. 

^bTU, technically unsatisfactory due to the presence of complex zones of complete and partial clearing. 

^cVREF, vancomycin-resistant E. faecium. 

^dVREF, vancomycin-resistant E. faecalis.