Scheme 3.
Reagents and conditions: a) CuI, K3PO4, N-(2-cyanophenyl)picolinamide, 21, DMSO, 46%; b) Cu(OAc)2, TMEDA, 14, DMSO, 90%; c) 10% Pd/C, H2, MeOH/THF (1:1), 95%; d) K2CO3, R-X, DMF; e) DIAD, PPh3, R-OH, THF; f) TMSCl, NaI, MeCN.
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