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. 2023 Sep 28;14(10):1434–1440. doi: 10.1021/acsmedchemlett.3c00335

Table 2. Liver Microsomal Stability Studies for Selected Compounds, Showing Percentage Remaining after 30 min and t1/2.

  4 36 41 43 45
HLM (t1/2) 4.9% (5.6) 91.7% (>30) 70.7% (>30) 48.0% (27.8) 19.5% (13)
MLM (t1/2) 0.7% (2.4) 73.3% (>30) 22.8% (14.7) 4.0% (3.0) 14.4% (11)
RLM (t1/2) 1.4% (4.8) 86.4% (>30) 90.2% (>30) 26.6% (19.8) 30.9% (18)