Table 2. Liver Microsomal Stability Studies for Selected Compounds, Showing Percentage Remaining after 30 min and t1/2.
4 | 36 | 41 | 43 | 45 | |
---|---|---|---|---|---|
HLM (t1/2) | 4.9% (5.6) | 91.7% (>30) | 70.7% (>30) | 48.0% (27.8) | 19.5% (13) |
MLM (t1/2) | 0.7% (2.4) | 73.3% (>30) | 22.8% (14.7) | 4.0% (3.0) | 14.4% (11) |
RLM (t1/2) | 1.4% (4.8) | 86.4% (>30) | 90.2% (>30) | 26.6% (19.8) | 30.9% (18) |