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Selectivity profile of compounds against other Fe(II)/2OG-dependent enzymes. Compounds 6, 12, and 13 were tested at 11 μM for inhibition of LH2 and other Fe(II)/2OG-dependent enzymes L230, JMJD2A, EGLN1, and FTO. Inhibition (%) is the percent decrease in the luminescence signal relative to DMSO controls in the luminescence-based selectivity assay. All samples were performed in duplicate, and error bars indicate standard error.
