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. 2023 Sep 22;14(10):1396–1403. doi: 10.1021/acsmedchemlett.3c00305

Figure 6.

Figure 6

Cell migration assay. Compound 13 suppresses cell migration of 344SQ lung adenocarcinoma cells (LH2b is highly expressed). A) Migrated 344SQ cells (WT and LH2 KO) in Boyden chambers were imaged after treatment with vehicle control (blank) and 20 μM of 13. B) Migrated 344SQ cells were counted after treatment with vehicle control (blank), 5 μM, and 20 μM of 13. Triplicates were performed for each condition, and the migration assay was repeated twice independently. When compared to 344SQ-WT cells treated with vehicle control (blank), 5 μM, and 20 μM of 13, a two-sided Student’s t-test analysis gave values of p = 0.000006, 0.001, and 0.07 for the corresponding concentrations of 13 in 344SQ LH2KO cells, respectively.