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Lead agonists were evaluated in a variety of functional assays. (A) Induction of IFNα and TNFα in human PBMCs. (B) Activation of hTLR7 and hTLR8 reporter cells. (C) Activation of hMDMs at 80, 400, and 2000 nM. (D) Activation of a mouse macrophage cell line (RAW dual).
