TABLE 2.

Pharmacokinetic parameters of DA-1131 after 1-min intravenous infusion of the drug at 50 mg/kg to control and U-ARF rats^a

Rat	AUC0–∞ (μg · min/ml)	AUMC0–∞ (μg · min2/ml)	Terminal t1/2 (min)	MRT (min)	CL (ml/min/kg)	CLR (ml/min/kg)	CLNR (ml/min/kg)	VSS (ml/kg)	XU0–8 (% of i.v.b dose)
Control (n = 10)	4,400 ± 610	49,600 ± 11,900	15.3 ± 1.21	11.2 ± 2.07	11.4 ± 1.78	4.95 ± 0.757	6.34 ± 1.35	124 ± 29.9	43.8 ± 4.27
U-ARF (n = 13)	13,000 ± 22,400c	948,000 ± 359,000c	61.5 ± 13.0c	71.0 ± 16.7c	3.84 ± 0.635c	0.000635 ± 0.0765c	3.80 ± 0.604d	259 ± 45.6c	1.54 ± 1.07c

^aValues are means ± standard deviations. 

^bi.v., intravenous. 

^cP < 0.001. 

^dP < 0.01.