TABLE 3.
Amount of DA-1131 recovered from 30 min after a 1-min intravenous infusion of the drug (50 mg/kg) to control and U-ARF ratsa
| Tissue | Amt (μg/ml of plasma or μg/g of tissue) recovered
|
Ratiob | |
|---|---|---|---|
| Control rats (n = 7) | U-ARF rats (n = 8) | ||
| Plasma | 19.8 ± 3.55 | 116 ± 8.30c | 5.86 |
| Brain | 1.25 ± 0.335 (0.0637 ± 0.0135)d | 3.82 ± 1.06c (0.0620 ± 0.0793) | 3.06 |
| Fat | 1.68 ± 0.685 (0.0844 ± 0.0288) | 16.7 ± 8.31c (0.143 ± 0.0697) | 9.94 |
| Heart | 3.17 ± 0.785 (0.161 ± 0.0266) | 14.9 ± 6.13c (0.128 ± 0.0499) | 4.70 |
| Kidney | 39.2 ± 7.92 (2.00 ± 0.279) | 10.5 ± 2.36c (0.0909 ± 0.0204c) | 0.268 |
| Large intestine | 2.67 ± 0.623 (0.140 ± 0.0486) | 13.7 ± 3.79c (0.117 ± 0.0246) | 5.13 |
| Liver | 7.84 ± 1.22 (0.402 ± 0.0568) | 44.7 ± 18.8c (0.387 ± 0.167) | 5.70 |
| Lung | 3.58 ± 3.84 (0.185 ± 0.200) | 17.5 ± 5.74c (0.152 ± 0.0492) | 4.89 |
| Mesentery | 3.76 ± 1.18 (0.189 ± 0.0376) | 23.3 ± 5.73c (0.199 ± 0.0359) | 6.20 |
| Muscle | 2.09 ± 0.471 (0.107 ± 0.0206) | 12.7 ± 3.56c (0.109 ± 0.0245) | 6.08 |
| Small intestine | 9.91 ± 3.65 (0.546 ± 0.351) | 24.2 ± 9.16e (0.210 ± 0.0850f) | 2.44 |
| Spleen | 1.07 ± 0.478 (0.0542 ± 0.0206) | 11.2 ± 2.40c (0.0961 ± 0.0144c) | 10.5 |
| Stomach | 3.50 ± 0.846 (0.178 ± 0.0366) | 23.7 ± 6.38c (0.205 ± 0.0460) | 6.77 |
a
Values are means ± standard deviations.
b
Ratio of amount for U-ARF rats to amount for control rats.
c
P < 0.001.
d
Numbers in parentheses are the mean ± standard deviation T/P ratios.
e
P < 0.01.
f
P < 0.05.