Table 6.
Toxicity profile of 1,8 cineole
| Classification | Target | Prediction |
|---|---|---|
| Toxicity endpoints | carcinogenicity | inactive |
| Toxicity endpoints | mutagenicity | inactive |
| Toxicity endpoints | cytotoxicity | inactive |
| Tox21-nuclear receptor signaling pathways | Aryl hydrocarbon Receptor (AhR) | inactive |
| Tox21-nuclear receptor signaling pathways | Androgen Receptor (AR) | inactive |
| Tox21-nuclear receptor signaling pathways | Androgen Receptor Ligand Binding Domain (AR-LBD) | inactive |
| Tox21-nuclear receptor signaling pathways | Peroxisome Proliferator-Activated Receptor Gamma (PPAR-Gamma) | inactive |
| Tox21-stress response pathways | Nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf2/ARE) | inactive |
| Tox21-stress response pathways | Heat Shock factor Response Element (HSE) | inactive |
| Tox21-stress response pathways | Mitochondrial Membrane Potential (MMP) | inactive |
| Tox21-stress response pathways | Phosphoprotein (Tumor Suppressor) p53 | inactive |
| Tox21-stress response pathways | ATPase family AAA domain-containing protein 5 (ATAD5) | inactive |
| LD50 | – | 2100 |
| −log10(LD50) | poison scale [0–13] | 3.3 |
| Predicted toxicity class |
|
5 |