Table 4.
Univariate and Multivariate Analysis for Overall Survival in the High-DCP Group (n=76)
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Sex (male) | 0.299 (0.037–2.432) | 0.259 | ||
| Age (≥65 years) | 0.600 (0.134–2.688) | 0.504 | ||
| PS (1) | 4.371 (1.504–12.701) | 0.007 | 6.310 (1.984–20.069) | 0.002 |
| ALBI grade (II) | 3.606 (1.139–11.423) | 0.029 | 3.794 (1.096–13.135) | 0.035 |
| BCLC (C) | 2.917 (0.652–13.044) | 0.161 | ||
| Tumor size (mm) (≥50) | 1.082 (0.240–4.885) | 0.918 | ||
| Tumor number (multiple) | 0.833 (0.174–3.983) | 0.819 | ||
| Macrovascular invasion (yes) | 1.613 (0.545–4.771) | 0.388 | ||
| DCP (mAU/mL) (≥400) | 0.637 (0.137–2.957) | 0.565 | ||
| DCP reduction >50% (yes) | 0.175 (0.061–0.498) | 0.001 | 0.221 (0.074–0.664) | 0.007 |
Note: Bold values are statistically significant (p<0.05).
Abbreviations: HR, hazard ratio; CI, confidence interval; PS, performance status; ALBI, albumin–bilirubin; BCLC, Barcelona Clinic Liver Cancer staging; DCP, des-gamma-carboxyprothrombin.