Table 1. Comparison of the number needed to treat for mortality reduction in HFrEF patients: MRA versus other drugs .

ACEI, angiotensin-converting enzyme; ARB, angiotensin-receptor blocker; GDMT, guideline-directed medical therapy; HFrEF, heart failure with reduced ejection fraction; MRA, mineralocorticoid receptor antagonist; NNT, number needed to treat

	MRA	Isosorbide dinitrate and hydralazine	ACEI/ ARB	Beta-blocker
NNT for mortality reduction	6	25	26	9