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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Oncogene. 2023 Jun 21;42(29):2237–2248. doi: 10.1038/s41388-023-02749-9

Figure 1. Hybrid E/M states are plastic and phenotypically heterogeneous.

Figure 1.

Representative model of hybrid E/M states. Early and late hybrid E/M states display the most plasticity, while mesenchymal and epithelial cells remain relatively stable. Invasiveness is highest in the mesenchymal population. Early hybrid E/M and late hybrid E/M cells likely exhibit the greatest metastatic potential. Hybrid E/M states show simultaneous expression of epithelial and mesenchymal genes. See also: Pastushenko et al. (14), Nieto et al. (2).

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