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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Oncogene. 2023 Jun 21;42(29):2237–2248. doi: 10.1038/s41388-023-02749-9

Figure 2. Hybrid E/M states contribute uniquely to invasion and metastasis.

Figure 2.

Both hybrid E/M and mesenchymal cells are able to invade through the extracellular matrix, however the hybrid E/M cells are most likely to seed at a metastatic site. Restoration of epithelial identity in a population of these cells allows for secondary tumor establishment and growth.