Table 1.
Characteristics of subjects at baseline, age-adjusted, by hypertension status (HTN2) and FOXO3 rs2802292 genotype
| Variables n | NT 1,237 | HTN2 1,451 | p | rs2802292 TT 1429 | rs2802292 TG/GG 1259 | p |
| FOXO3 TG/GG (%)1 | 46.1 | 47.5 | 0.47 | – | – | – |
| Hypertension (%)1 | – | – | – | 53.3 | 54.7 | 0.47 |
| Age (y±SD)1 | 76.7±3.9 | 77.1±4.1 | 0.031 | 76.7±3.9 | 77.2±4.2 | 0.0024 |
| Education (y) | 10.8±3.1 | 10.7±3.1 | 0.52 | 10.8±3.1 | 10.7±3.2 | 0.41 |
| APOE ɛ4 carriage (%) | 17.8 | 19.2 | 0.37 | 18.5 | 18.7 | 0.89 |
| Cognitive (CASI) score | 86.7±9.1 | 86.5±7.9 | 0.65 | 86.8±8.1 | 86.3±8.9 | 0.17 |
| BMI (kg/m2) | 23.3±3.1 | 24.1±2.9 | <0.0001 | 23.6±3 | 23.8±2.9 | 0.12 |
| Systolic blood pressure (mmHg) | 136.4±13.4 | 160.7±21.4 | <0.0001 | 148.8±21.7 | 150.3±21.9 | 0.070 |
| Diastolic blood pressure (mmHg) | 76.3±8.3 | 84.4±11.1 | <0.0001 | 80.5±10.5 | 80.9±10.9 | 0.27 |
| Smoking (pack-years) | 24.4±33.9 | 26.5±34.1 | 0.13 | 24.9±33.5 | 26.3±34.6 | 0.28 |
| Alcohol consumption (ounces/mo.) | 14.6±31 | 20.9±44.1 | <0.0001 | 17.5±38.1 | 18.5±39.4 | 0.52 |
| Physical activity index | 31.4±4.8 | 31.2±4.6 | 0.41 | 31.3±4.8 | 31.4±4.6 | 0.70 |
| Fasting plasma glucose (mg/dl) | 109.9±25.2 | 115.5±30.5 | <0.0001 | 111.7±26.9 | 114.3±29.8 | 0.022 |
| Diabetes (%) | 22.5 | 33.1 | <0.0001 | 26.6 | 30.1 | 0.045 |
| Stroke (%) | 2.3 | 3.8 | 0.021 | 3.7 | 2.4 | 0.058 |
| CHD (%) | 17.5 | 21.2 | 0.016 | 21 | 17.8 | 0.035 |
| Depressive symptoms | 9.4 | 9.3 | 0.95 | 8.9 | 9.8 | 0.45 |
| Loss to follow-up1,2 (%) | 19.2 | 20.97 | 0.20 | 20.12 | 20.22 | 0.95 |
NT: normotensive; HTN2: SBP/DBP ≥160/95 or on anti-hypertensive medication. 1Not adjusted for age. 2Loss to follow-up by hypertension status and FOXO3 genotypes were based on 2,688 eligible subjects + 679 subjects lost during follow-up.