Table 2.
Main effects (HR and 95% confidence intervals) of late-life hypertension status, BP variables, and FOXO3 rs2802292 longevity genotype, on risk of all-cause dementia, Alzheimer’s disease and vascular dementia
| Model A | All-cause dementia | Alzheimer’s disease | Vascular dementia | |||
| Variable | HR (95% CI)1 | p | HR (95% CI) | p | HR (95% CI) | p |
| HTN1 | 1.05 (0.89–1.25) | 0.55 | 0.97 (0.79–1.18) | 0.73 | 1.78 (1.05–2.99) | 0.032 |
| HTN2 | 1.02 (0.88–1.18) | 0.79 | 0.96 (0.81–1.15) | 0.67 | 1.76 (1.16–2.66) | 0.0079 |
| SBP ≥140 | 0.96 (0.83–1.13) | 0.65 | 0.87 (0.73–1.05) | 0.15 | 1.61 (1.03–2.54) | 0.038 |
| SBP ≥160 | 0.96 (0.82–1.13) | 0.63 | 0.84 (0.69–1.02) | 0.072 | 1.88 (1.26–2.79) | 0.0018 |
| DBP ≥90 | 0.96 (0.80–1.16) | 0.68 | 0.89 (0.71–1.11) | 0.30 | 1.50 (0.96–2.32) | 0.074 |
| DBP ≥95 | 0.73 (0.56–0.96) | 0.023 | 0.65 (0.47–0.91) | 0.011 | 1.53 (0.88–2.65) | 0.13 |
| FOXO3_G | 0.88 (0.76–1.03) | 0.10 | 0.87 (0.73–1.04) | 0.12 | 0.77 (0.52–1.14) | 0.19 |
| Haplotype | 0.89 (0.73–1.09) | 0.25 | 0.87 (0.69–1.10) | 0.26 | 0.86 (0.51–1.45) | 0.57 |
| Model B | All-cause dementia | Alzheimer’s disease | Vascular dementia | |||
| Variable | HR (95% CI)* | p | HR (95% CI) | p | HR (95% CI) | p |
| HTN1 | 0.98 (0.82–1.18) | 0.84 | 0.88 (0.71–1.09) | 0.23 | 2.03 (1.11–3.69) | 0.020 |
| HTN2 | 0.93 (0.80–1.09) | 0.39 | 0.88 (0.73–1.06) | 0.19 | 1.71 (1.08–2.71) | 0.022 |
| SBP ≥140 | 0.92 (0.78–1.09) | 0.33 | 0.83 (0.68–1.00) | 0.051 | 1.74 (1.05–2.89) | 0.032 |
| SBP ≥160 | 0.89 (0.75–1.06) | 0.20 | 0.77 (0.63–0.95) | 0.015 | 1.80 (1.17–2.78) | 0.0076 |
| DBP ≥90 | 0.92 (0.75–1.12) | 0.39 | 0.84 (0.67–1.07) | 0.16 | 1.62 (1.00–2.62) | 0.051 |
| DBP ≥95 | 0.67 (0.50–0.90) | 0.0073 | 0.59 (0.41–0.84) | 0.004 | 1.57 (0.85–2.89) | 0.15 |
| FOXO3_G | 0.88 (0.75–1.03) | 0.099 | 0.87 (0.72–1.05) | 0.14 | 0.75 (0.49–1.16) | 0.19 |
| Haplotype | 0.87 (0.70–1.07) | 0.19 | 0.85 (0.66–1.08) | 0.19 | 0.84 (0.48–1.48) | 0.56 |
Model A: HR (95% CI) were estimated from multivariate Cox models adjusted for baseline variables: age, education (years), CASI score, prevalent stroke, APOE ɛ4, and FOXO3_G (having the G-allele of FOXO3 SNP rs2802292, i.e., genotype TG or GG). Model B: HR (95% CI) were estimated from multivariate Cox models adjusted for baseline variables: age, education (years), APOE ɛ4, CASI score, BMI, plasma glucose, smoking (pack-year), alcohol drinking (ounces/month), physical activity index, and prevalent diabetes, CHD, stroke, and depressive symptoms. HTN1, SBP/DBP ≥140/90 mmHg or the self-reported use of anti-hypertensive medications; HTN2, SBP/DBP ≥160/95 mmHg or the self-reported use of anti-hypertensive medications; FOXO3_G, having the G allele of FOXO3 SNP rs2802292, i.e., genotype TG or GG.