Table 3.
Incidence of dementia (per 1,000 person-years) of FOXO3 rs2802292 genotypes stratified by late-life hypertension status
| A | Normotensive | Hypertensive (HTN2) | ||||
| TT | TG/GG | p 1 | TT | TG/GG | p 1 | |
| Total n values | 667 | 570 | – | 762 | 689 | – |
| All-cause dementia – n | 184 | 153 | – | 198 | 190 | – |
| age-adjusted incidence | 34.4 | 32.3 | 0.60 | 33.8 | 33.1 | 0.24 |
| Alzheimer’s disease – n | 127 | 119 | – | 144 | 123 | – |
| age-adjusted incidence | 23. 5 | 25.1 | 0.58 | 24.3 | 21.3 | 0.036 |
| Vascular dementia – n | 22 | 12 | – | 38 | 32 | – |
| age-adjusted incidence | 4.27 | 2.68 | 0.16 | 6.64 | 5.61 | 0.40 |
| B | Normotensive | Hypertensive (HTN1) | ||||
| TT | TG/GG | p 1 | TT | TG/GG | p 1 | |
| Total n value | 361 | 313 | – | 1068 | 946 | – |
| All-cause dementia – n | 96 | 82 | – | 286 | 261 | – |
| Age-adjusted incidence | 34.5 | 31.6 | 0.90 | 34.2 | 32.8 | 0.14 |
| Alzheimer’s disease – n | 68 | 65 | – | 203 | 177 | – |
| age-adjusted incidence | 23.5 | 25.0 | 0.40 | 24.2 | 22.2 | 0.071 |
| Vascular dementia – n | 10 | 7 | – | 50 | 37 | – |
| age-adjusted incidence | 4.36 | 2.93 | 0.65 | 6.06 | 4.72 | 0.16 |
1p value for test of incidence rates between FOXO3 genotypes (TT versus TG/GG), estimated using Cox proportional hazard models adjusting for age within each hypertension status. HTN1, SBP/DBP ≥140/90 mmHg or the self-reported use of anti-hypertensive medications; HTN2, SBP/DBP ≥160/95 mmHg or the self-reported use of anti-hypertensive medications.