Table 4.

Probability (p) values for the interaction term between FOXO3 rs2802292 longevity genotype with late– life BP variables on incident all-cause dementia, Alzheimer’s disease, and vascular dementia

	All– cause dementia	Alzheimer’s disease	Vascular dementia
Interaction term	p †	p	p
BP*FOXO3_G
HTN1*FOXO3_G	0.10	0.051	0.25
HTN2*FOXO3_G	0.070	0.0061	0.81
SBP140*FOXO3_G	0.15	0.061	0.84
SBP160*FOXO3_G	0.023	0.0055	0.58
DBP90*FOXO3_G	0.039	0.0021	0.31
DBP95*FOXO3_G	0.65	0.51	0.57

^†p value for the interaction term estimated from the full Cox models for late-life BP variable and FOXO3 genotype, adjusting for baseline variables: age, education (years), APOE ɛ4, CASI score, BMI, plasma glucose, smoking (pack– year), alcohol drinking (ounces/month), physical activity index, and prevalent diabetes, CHD, stroke, and depressive symptoms. HTN1, SBP/DBP ≥140/90 mmHg or the self-reported use of anti-hypertensive medications; HTN2: SBP/DBP ≥160/95 mmHg or the self-reported use of anti-hypertensive medications; SBP140, SBP ≥140; SBP160, SBP ≥160; DBP90, DBP ≥90; DBP95, DBP ≥95; *, interaction term; FOXO3_G, rs2802292 (TG/GG).