Table 1.
MG Recently diagnosed n = 20 | MG Chronic n = 19 | MG Seronegative n = 14 | CPEO n = 6 | OPMD n = 6 | GO n = 6 | Healthy controls n = 16 | p-value | |
Age (yrs) | 59±19 | 51±16 | 57±9 | 49±14 | 62±10 | 44±12 | 54±13 | 0.243 |
Sex | 0.754 | |||||||
Female | 7 (35%) | 9 (47%) | 7 (50%) | 3 (50%) | 4 (67%) | 4 (67%) | 9 (56%) | |
Male | 13 (65%) | 10 (53%) | 7 (50%) | 3 (50%) | 2 (33%) | 2 (33%) | 7 (44%) | |
Phenotype | 0.105 | |||||||
Ocular | 12 (60%) | 6 (32%) | 9 (64%) | - | - | - | - | |
Generalized | 8 (40%) | 13 (68%) | 5 (36%) | - | - | - | - | |
Disease duration (months) | 4.0±2.2 | 75.6±87.9 | 25.6±60.5 | - | - | 22.8±35.9* | - | < 0.0001 |
MG-ADL | 5.8±3.3 | 5.5±4.2 | 5.0±2.7 | - | - | - | - | 0.791 |
MG-ADL (ocular items) | 2.8±1.1 | 1.7±0.8 | 2.9±1.2 | 0.165 | ||||
QMG | 9.2±6.0 | 9.8±7.7 | 8.3±4.6 | - | - | - | - | 0.812 |
QMG (ocular items) | 2.2±0.7 | 1.2±0.7 | 2.5±1.0 | 0.365 | ||||
Pyridostigmine on study day | 25% | 15% | 14% | - | - | - | - | 0.680 |
Hess-chart abnormalities | 15 | 15 | 11 | 6 | 5 | 5 | 0 | |
Synoptophore abnormalities | 9 | 10 | 7 | 6 | 5 | 1 | 0 | |
Ptosis at visit | 10 | 5 | 5 | 5 | 5 | 0 | 0 |
*Two Graves’ orbitopathy patients were diagnosed longer than>one year ago and four patients<one year ago.