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. 2023 Oct 13;11:e16239. doi: 10.7717/peerj.16239

Table 1. Summary of ALOX15 inhibitors in a variety of diseases.

Inhibitors Function Diseases
Baicalin ERK, ROS ↓ Neurodegenerative disorder diseases
Behavioral deficits ↓ Embolic stroke in rabbits; AIS
PPAR-γ expression ,translocation ↓ Ischemia-reperfusion injury
VEGF ↓ Angiogenesis of prostate cancer
PD146176 Plasma 12-HETE ↓ Vascular calcification
EMT ↓ ECRS with nasal polyps
Inflammation, fibrosis, macrophages infiltration ↓ UUO treatment of Alox15 knockout mice
BHPP Urinary 12-HETE,12-HETE/cr excretion ↓ DKD
NDGA Oxidative stress index ↓ DKD
ML351 Glutamate oxidative toxicity ↓ Ischemic stroke
ML355 PAR-4 -induced aggregation, calcium mobilization, 12-HETE in β-cells ↓ DM; Anti-platelet therapy