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. 2023 Aug 29;7(1):957–972. doi: 10.3233/ADR-220098

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© 2023 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Comparison of key regulators in HC from AD, Demented, and Control samples. For GSE4757: (A) multidimension scaling (MDS) comparing tangle-free and tangle samples; (B) ontological enrichment using GOBP library; and (C) TF-target enrichment using the ECC library. For Allen Brain Atlas samples: (D) hippocampus (HC) z-score expression values from Allen Brain Atlas’ ADT data for NRF1, REST, and SOX2 are plotted for two conditions (1) Non-demented control (NDC) (Braak I-II) and (2) probable AD samples (AD) (Braak III-VI). Traumatic brain injury samples were excluded for all conditions assessed.