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. 2023 Oct 2;11:1281266. doi: 10.3389/fpubh.2023.1281266

Table 1.

COVID-19 vaccination and health outcomes in the research group with cognitive disorders compared to the control group.

Research group Control group
Unvaccinated Vaccinated Unvaccinated Vaccinated
n % n % p value n % n % p value
Sample size 3,543 16.86% 17,470 83.14% 11,104 17.98% 50,666 82.02%
Male 1,407 39.70% 6,965 39.87% 0.86 5,091 45.85% 23,494 46.37% 0.37
Female 2,136 60.30% 10,505 60.13% 0.86 6,013 54.15% 27,172 53.63% 0.37
Age Mean (SD) 82.1 (5.46) 80.62 (5.58) p < 0.001 77.88 (6.17) 75.98 (5.18) p < 0.001
Mortality 1852 52.27% 1,241 7.10% p < 0.001 1,508 13.58% 936 1.85% p < 0.001
Positive for COVID-19 1,072 30.26% 6,492 37.16% p < 0.001 1922 17.31% 18,873 37.25% p < 0.001
Moved from MCI to dementia 697 19.67% 4,029 23.06% p < 0.001
Purchased antipsychiatry drugs 1,328 37.48% 4,967 28.43% p < 0.001 506 4.56% 2,158 4.26% 0.17
Prescribed antipsychotics drugs 986 27.83% 4,171 23.88% p < 0.001 305 2.75% 1866 3.68% p < 0.001
Purchased antidepressants 1,553 43.83% 9,599 54.95% p < 0.001 1,221 11.00% 12,586 24.84% p < 0.001
Prescribed anti-depressants 1,354 38.22% 9,040 51.75% p < 0.001 1,146 10.32% 12,704 25.07% p < 0.001
Depression diagnosis 1,054 29.75% 5,750 32.91% p < 0.01 1,250 11.26% 5,185 10.23% p < 0.01
Home treatments 912 25.74% 1892 10.83% p < 0.001 468 4.21% 630 1.24% p < 0.001
Bone fractures 257 7.25% 2014 11.53% p < 0.001 364 3.28% 4,049 7.99% p < 0.001
Registered blood pressure 2,936 82.87% 13,743 78.67% p < 0.05 7,714 69.47% 35,135 69.35% 0.89
Registered COPD 329 9.29% 1786 10.22% 0.11 1,154 10.39% 4,368 8.62% p < 0.001
Registered diabetes 1,472 41.55% 6,748 38.63% p < 0.05 3,847 34.65% 15,987 31.55% p < 0.001
Registered Immunosuppression 893 25.20% 3,626 20.76% p < 0.001 3,082 27.76% 8,470 16.72% p < 0.001
Registered obesity 549 15.50% 4,617 26.43% p < 0.001 1,551 13.97% 15,090 29.78% p < 0.001

MCI, mild cognitive impairment.