. 2023 Oct 2;11:1281266. doi: 10.3389/fpubh.2023.1281266

Table 2.

Cox ratio analysis reveals the influence of COVID-19 vaccination on health outcomes and medication usage in the research group with cognitive disorders.

		Not vaccinated		Vaccinated		Adjusted hazard ratio
		n	%	n	%	coef	coef lower 95%	coef upper 95%	p value
		3,543	16.86%	17,470	83.14%	−2.99	−3.12	−2.86	p < 0.001
Mortality	No	1,691	47.73%	16,229	92.90%
Mortality	Yes	1852	52.27%	1,241	7.10%
Positive to COVID-19	No	2,471	69.74%	10,978	62.84%	−1.1	−1.25	−0.96	p < 0.001
Positive to COVID-19	Yes	1,072	30.26%	6,492	37.16%	−1.1	−1.25	−0.96	p < 0.001
Moved from MCI to dementia	No	2,846	80.33%	13,441	76.94%	0.17	0.04	0.3	p < 0.01
Moved from MCI to dementia	Yes	697	19.67%	4,029	23.06%	0.17	0.04	0.3	p < 0.01
Purchased antipsychiatry drugs	No	2,215	62.52%	12,503	71.57%	1.1	0.92	1.28	p < 0.001
Purchased antipsychiatry drugs	Yes	1,328	37.48%	4,967	28.43%	1.1	0.92	1.28	p < 0.001
Prescribed antipsychotics drugs	No	2,557	72.17%	13,299	76.12%	−0.82	−1.02	−0.63	p < 0.001
Prescribed antipsychotics drugs	Yes	986	27.83%	4,171	23.88%	−0.82	−1.02	−0.63	p < 0.001
Purchased antidepressants	No	1990	56.17%	7,871	45.05%	0.54	0.35	0.74	p < 0.001
Purchased antidepressants	Yes	1,553	43.83%	9,599	54.95%	0.54	0.35	0.74	p < 0.001
Prescribed antidepressants	No	2,189	61.78%	8,430	48.25%	−0.42	−0.62	−0.22	p < 0.001
Prescribed antidepressants	Yes	1,354	38.22%	9,040	51.75%	−0.42	−0.62	−0.22	p < 0.001
Depression diagnosis	No	2,489	70.25%	11,720	67.09%	−0.25	−0.38	−0.12	p < 0.001
Depression diagnosis	Yes	1,054	29.75%	5,750	32.91%	−0.25	−0.38	−0.12	p < 0.001
Home treatments	No	2,631	74.26%	15,578	89.17%	0.25	0.11	0.39	p < 0.001
Home treatments	Yes	912	25.74%	1892	10.83%	0.25	0.11	0.39	p < 0.001
Bone fractures	No	3,286	92.75%	15,456	88.47%	−0.14	−3.22	2.94	0.46
Bone fractures	Yes	257	7.25%	2014	11.53%	−0.14	−3.22	2.94	0.46
Hip fracture	No	3,286	92.75%	15,456	88.47%	−0.14	−3.22	2.94	0.46
Hip fracture	Yes	257	7.25%	2014	11.53%	−0.14	−3.22	2.94	0.46
Registered blood pressure	No	607	17.13%	3,727	21.33%	0.07	−0.07	0.22	0.17
Registered blood pressure	Yes	2,936	82.87%	13,743	78.67%	0.07	−0.07	0.22	0.17
Registered COPD	No	3,214	90.71%	15,684	89.78%	0.19	0.01	0.37	p < 0.05
Registered COPD	Yes	329	9.29%	1786	10.22%	0.19	0.01	0.37	p < 0.05
Registered diabetes	No	2071	58.45%	10,722	61.37%	0.36	0.24	0.48	p < 0.001
Registered diabetes	Yes	1,472	41.55%	6,748	38.63%	0.36	0.24	0.48	p < 0.001
Registered immunosuppression	No	2,650	74.80%	13,844	79.24%	0.52	0.4	0.64	p < 0.001
Registered immunosuppression	Yes	893	25.20%	3,626	20.76%	0.52	0.4	0.64	p < 0.001
Registered obesity	No	2,994	84.50%	12,853	73.57%	−5.14	−6.41	−3.87	p < 0.001
Registered obesity	Yes	549	15.50%	4,617	26.43%	−5.14	−6.41	−3.87	p < 0.001

The Cox proportional hazard model was constructed for the outcome events of the two study groups considering a previous history of outcome events, having tested positive to COVID-19, using antipsychotics drugs, using antidepressants, having depression diagnosis, bone fractures, and different registered medical conditions as covariates, weighted by the inverse probability of full vaccination.