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Methylation of SmE by recombinant methylosome. (A–C) Recombinant PRMT5/MEP50 complex was incubated with indicated Sm or Lsm heterodimers and 3H SAM either in the absence or presence of pICln and SmE/F/G heterotrimer, as indicated. Protein methylation was detected, as described in the legend for Figure 2. Coomassie Blue stained gels and fluorograms are shown at the top and bottom, respectively.
