TABLE 5.

ROC analysis of QStat parameters for various ROTEM thresholds

Model	QStat cutoff value (hPa)	N (yes/no)	AUC	Sensitivity	Specificity	NPV
EXTEM A20<25 mm vs. CS	CS<3.8 (2.5, 5.1)	10/383	0.94 (0.88, 1.00)	0.90 (0.71, 1.00)	0.86 (0.83, 0.90)	0.99 (0.99, 1.00)
EXTEM A20<30 mm vs. CS	CS<5.3 (4.6, 6.0)	26/367	0.95 (0.91, 0.95)	0.88 (0.76, 1.00)	0.9 (0.87, 0.93)	0.99 (0.98, 1.00)
EXTEM A20<35 mm vs. CS	CS<6.9 (6.5, 7.3)	58/335	0.95 (0.93, 0.97)	0.95 (0.90, 1.00)	0.86 (0.78, 0.95)	0.99 (0.94, 1.00)
EXTEM A20<40 mm vs. CS	CS<7.9 (7.6, 8.2)	106/287	0.95 (0.94, 0.95)	0.91 (0.85, 0.96)	0.90 (0.86, 0.93)	0.96 (0.94, 0.99)
EXTEM A20<45 mm vs. CS	CS<11.1 (10.5, 11.7)	178/215	0.95 (0.93, 0.97)	0.97 (0.94, 0.99)	0.84 (0.79, 0.89)	0.97 (0.94, 0.99)
FIBTEM A20<4 mm vs. FCS	FCS<0.5 (0.4, 0.6)	9/386	0.94 (0.89, 1.00)	0.89 (0.68, 1.00)	0.92 (0.90, 0.95)	0.99 (0.99, 1.00)
FIBTEM A20<6 mm vs. FCS	FCS<0.8 (0.7, 0.9)	57/338	0.94 (0.90, 0.97)	0.91 (0.84, 0.99)	0.85 (0.81, 0.89)	0.98 (0.97, 1.00)
FIBTEM A20<8 mm vs. FCS	FCS<1.0 (0.9, 1.1)	121/274	0.93 (0.91, 0.96)	0.88 (0.82, 0.93)	0.89 (0.86, 0.93)	0.94 (0.91, 0.97)
FIBTEM A20<10 mm vs. FCS	FCS<1.4 (1.3, 1.5)	181/214	0.94 (0.92, 0.96)	0.94 (0.90, 0.97)	0.79 (0.74, 0.85)	0.94 (0.90, 0.97)
FIBTEM A20<12 mm vs. FCS	FCS<1.6 (1.5, 1.7)	246/149	0.94 (0.91, 0.96)	0.89 (0.85, 0.93)	0.85 (0.79, 0.90)	0.82 (0.76, 0.88)

Note: Numbers in (,) represent the 95% CIs.

Abbreviations: CS, clot stiffness; FCS, fibrinogen contribution to clot stiffness. NPV, negative predictive value